Nature & Wildlife


Co-maturation of P300 component and delta band

Co-maturation of P300 component and delta band
of 1

Please download to get full document.

View again

All materials on our website are shared by users. If you have any questions about copyright issues, please report us to resolve them. We are always happy to assist you.
  Poster Abstracts / Int. J. Devl Neuroscience 28 (2010) 655–719  659 matter centered at the anterior cingulate cortex were determinedusing LC model. Participants completed 9 subtests of the Califor-nia Computerized Assessment Package (CalCAP) to assess reactiontime, working-memory, and attention. Correlations between age,imaging, and cognitive measures were determined (  p <0.05 signif-icance).The medial-orbital-frontal cortex thinned with age ( r  = − 0.37).Improved CalCAP performance on 2 subtests ( r  >0.34) and highern-acetyl-aspartate (NAA) levels ( r  = − 0.32) were associated withthis thinning. The superior-frontal cortex also thinned with age( r  =-0.45) with corresponding improved performance on 4 sub-tests ( r  >0.33) and higher glutamate+glutamine (GLX) levels. Thesuperior-frontal cortex volume also decreased with age ( r  = − 0.42)and was associated with improved performance on 8 subtests( r  >0.30). Smaller volumes of the frontal pole were observed inolder participants ( r  = − 0.31), which correlated with improvedperformance on 1 test ( r  =0.31). Smaller volumes in the medial-orbital-frontal cortex correlated with improved performance on 4subtests ( r  >0.35) and higher NAA levels ( r  = − 0.31).These results emphasize that the frontal cortex is still devel-oping into the 3 rd decade of life. In addition, our data suggestthat cortical pruning (thinning and volume reductions) duringperiadolescent brain development is associated with increasingconcentrations of neuronal markers (NAA and GLX), and improvedperformance on higher cognitive functions, possibly due to morecompact and efficient neuronal function and enhanced neuronalintegrity.doi:10.1016/j.ijdevneu.2010.07.052 [P1.12]Broad band indices of human spontaneous EEG maturationaltrends E.I. Rodriguez-Martinez, C.I. Barriga-Paulino, C.M. Gómez ∗ University of Sevilla, SpainKeywords:  Spontaneous EEG; Power spectral density; Principalcomponent analysis; Overall developmental patternsThispaperattemptstoanalyzethematurationofthehumanEEGinthefrequencyspectrumbetween0and20Hz,withoutconsider-ing the division of the classical brain rhythms. Forty-eight subjectswererecorded3minofspontaneousEEG(24childrenand24youngadults).Thecomparisonofthepowerspectraldensity(PSD)amongchildrenandyoungadultsshowedahigherPSDinchildrenthaninadults.TherelativePSDshowedamorecomplexpatternincludingadecreaseofdeltaandthetarhythmsandanincreaseinbetarhythmfor adults with respect to children. Both absolute and normalizedPSD showed significant correlations with age indicating that theseparameters can be considered as predictors of the EEG matura-tion. The correlation matrix and the Principal Component Analysis(PCA) were used to demonstrate the possible structure of the EEGfrequencies PSD and if it exists maturational changes in this struc-ture. The correlation matrix of the normalized EEG demonstratedan inverse relationship between delta and alpha frequencies. PCAanalysisconfirmedthatthisrelationshipisalsopresentintheabso-lute PSD. Finally the maturational pattern of human EEG seems totend towards a roof value in the PSD and to an extinction of theinverse relationship between delta and alpha rhythms.doi:10.1016/j.ijdevneu.2010.07.053 [P1.13]Co-maturation of P300 component and delta band C.I. Barriga-Paulino ∗ , A.B. Flores, C.M. Gómez University of Seville, SpainKeywords:  Cerebral maturation; Spontaneous EEG; P300 compo-nent; Cluster analysisWe pretended to test if the maturation of the spontaneous EEGis related to the P300 component maturation. For that sponta-neous EEG rhythms power spectral density (PSD) and the P300component were obtained and analyzed by means of multivariatetechniques.Thirty-eight subjects (18 children between 8 and 13 years oldand 20 young adults between 18 and 23 years old) participatedin the experiment. The P3b amplitudes were obtained in valid andinvalidtrialsofacentralcuePosnerparadigminchildrenandyoungadults. To analyze the relationship between the spontaneous EEGbands spectral power and the P300 amplitude the Principal Com-ponent Analysis (PCA) and the clusters analysis were used.The results showed that in both age groups the amplitude of the posterior positivity (340–440ms) was greater in the invalidcondition and the P3b component was greater in children than inyoung adults. Respect to the spontaneous activity, it was observedthat children presented higher spectral power than young adults,especially in the lower frequency bands (delta and theta). The treediagramintheclusteranalysisrevealedthatthereisacloseassoci-ation between the P300 component amplitude and the delta band.Theresultsofthetreediagramobtainedfromtheclusteranalysissuggest that the P3b maturation is closely associated to the mat-uration of the delta band, possibly because both P300 and delta,share some neural generators.doi:10.1016/j.ijdevneu.2010.07.054 [P1.14]Preparatoryactivityandevaluationofspatialvalidity–invalidity indexed by ERPs in children and young adults A.B. Flores ∗ , C.M. Gómez University of Seville, SpainKeywords:  ERPs;Contingentnegativevariation;ChilddevelopmentThe present study investigated neural preparatory activationand evaluation of target stimuli in central cue Posner’s paradigm.Themainobjectivewastoassesspossibledifferencesbetweenchil-dren and young adults.The preparatory activation was evaluated with late and earlycontingent negative variations (CNV). The CNV amplitudes werecompared between 16 healthy children and 17 healthy youngadults.TheP3aandP3bwereanalyzedin18childrenand20youngadults.BehavioralRTsanderrorswereanalyzed.TheearlyandlatecomponentsoftheCNVintheperiodbetweencueandtargetwereanalyzed. The P3a and P3b amplitudes were analyzed in the validand invalid trials.Thepreparatoryactivationofthespecificneuralresources(task-specific pattern of the CNV), motor and sensory was recorded inyoung adults while only the sensory anticipation component wasrecorded in children. Also, a positive parietal component appearedin children during the CNV period indicating a differential neuralactivation in children with respect to young adults. This differen-tial activation was confirmed by dipole localization. Young adultsshowedmoreactivationinanterior(P3a)andposterior(P3b)areasin the invalid than the valid condition, whereas children only
Related Documents
View more
Related Search
We Need Your Support
Thank you for visiting our website and your interest in our free products and services. We are nonprofit website to share and download documents. To the running of this website, we need your help to support us.

Thanks to everyone for your continued support.

No, Thanks